Coulomb entangler and entanglement testing network for waveguide qubits

We present a small network for the testing of the entanglement of two ballistic electron waveguide qubits. The network produces different output conditional on the presence or absence of entanglement. The structure of the network allows for the determination of successful entanglement operations through the measurement of the output of a single qubit. We also present a simple model of a dynamic coulomb-like interaction and use it to describe some characteristics of a proposed scheme for the entanglement of qubits in ballistic electron waveguides.Comment: 12 pages of text plus 7 figures: total 19 page

Optimized Analytical Procedures for the Untargeted Metabolomic Profiling of Human Urine and Plasma by Combining Hydrophilic Interaction (HILIC) and Reverse-Phase Liquid Chromatography (RPLC)-Mass Spectrometry.

Profiling of body fluids is crucial for monitoring and discovering metabolic markers of health and disease and for providing insights into human physiology. Since human urine and plasma each contain an extreme diversity of metabolites, a single liquid chromatographic system when coupled to mass spectrometry (MS) is not sufficient to achieve reasonable metabolome coverage. Hydrophilic interaction liquid chromatography (HILIC) offers complementary information to reverse-phase liquid chromatography (RPLC) by retaining polar metabolites. With the objective of finding the optimal combined chromatographic solution to profile urine and plasma, we systematically investigated the performance of five HILIC columns with different chemistries operated at three different pH (acidic, neutral, basic) and five C18-silica RPLC columns. The zwitterionic column ZIC-HILIC operated at neutral pH provided optimal performance on a large set of hydrophilic metabolites. The RPLC columns Hypersil GOLD and Zorbax SB aq were proven to be best suited for the metabolic profiling of urine and plasma, respectively. Importantly, the optimized HILIC-MS method showed excellent intrabatch peak area reproducibility (CV < 12%) and good long-term interbatch (40 days) peak area reproducibility (CV < 22%) that were similar to those of RPLC-MS procedures. Finally, combining the optimal HILIC- and RPLC-MS approaches greatly expanded metabolome coverage with 44% and 108% new metabolic features detected compared with RPLC-MS alone for urine and plasma, respectively. The proposed combined LC-MS approaches improve the comprehensiveness of global metabolic profiling of body fluids and thus are valuable for monitoring and discovering metabolic changes associated with health and disease in clinical research studies

Why Are Drugs More Profitable Than Vaccines?

In a simple representative consumer model, vaccines and drug treatments yield the same revenue for a pharmaceutical manufacturer, implying that the firm would have the same incentive to develop either ceteris paribus. We provide more realistic models in which the revenue equivalence breaks down for two reasons. First, drug treatments are sold after the firm has learned who has contracted the disease; in the case of heterogeneous consumers who vary with respect to the probability of contracting the disease, there is less asymmetric information to prevent the firm from extracting consumer surplus with drug treatments than with vaccines. We prove that, due to this aspect of pharmaceutical pricing, the ratio of drug-treatment to vaccine revenue can be arbitrarily high; we calculate that the ratio is about two to one for empirical distributions of HIV risk. The second reason for the breakdown of revenue equivalence is that vaccines are more likely to interfere with the spread of the disease than are drug treatments, thus reducing demand for the product. By embedding an economic model within a standard dynamic epidemiological model, we show that the steady-state flow of revenue is greater for drug treatments than for vaccines.

Thermoelastic vibration test techniques

The structural integrity of proposed high speed aircraft can be seriously affected by the extremely high surface temperatures and large temperature gradients throughout the vehicle's structure. Variations in the structure's elastic characteristics as a result of thermal effects can be observed by changes in vibration frequency, damping, and mode shape. Analysis codes that predict these changes must be correlated and verified with experimental data. The experimental modal test techniques and procedures used to conduct uniform, nonuniform, and transient thermoelastic vibration tests are presented. Experimental setup and elevated temperature instrumentation considerations are also discussed. Modal data for a 12 by 50 inch aluminum plate heated to a temperature of 475 F are presented. These data show the effect of heat on the plate's modal characteristics. The results indicated that frequency decreased, damping increased, and mode shape remained unchanged as the temperature of the plate was increased

Determination of the effects of heating on modal characteristics of an aluminum plate with application to hypersonic vehicles

The structural integrity of proposed high speed aircraft can be seriously affected by the extremely high surface temperatures and large temperature gradients throughout the vehicle's structure. Variations in the structure's elastic characteristics as a result of thermal effects can be seen by changes in vibration characteristics. Analysis codes that predict these changes must be correlated and verified with experimental data. Analytical and experimental modal test results are given from uniform, nonuniform, and transient thermoelastic vibration tests of a 12 x 50 x 0.19 aluminum plate. The data show the effect of heat on the modal characteristics of the plate. The results showed that frequencies decreased, damping increased, and mode shapes remained unchanged as the temperature of the plate increased. Analytical predictions provided good correlation with experimental results

Corepressor diversification by alternative mRNA splicing is species specific.

BackgroundSMRT and NCoR are corepressor paralogs that help mediate transcriptional repression by a variety of transcription factors, including the nuclear hormone receptors. The functions of both corepressors are extensively diversified in mice by alternative mRNA splicing, generating a series of protein variants that differ in different tissues and that exert different, even diametrically opposite, biochemical and biological effects from one another.ResultsWe report here that the alternative splicing previously reported for SMRT appears to be a relatively recent evolutionary phenomenon, with only one of these previously identified sites utilized in a teleost fish and a limited additional number of the additional known sites utilized in a bird, reptile, and marsupial. In contrast, extensive SMRT alternative splicing at these sites was detected among the placental mammals. The alternative splicing of NCoR previously identified in mice (and shown to regulate lipid and carbohydrate metabolism) is likely to have arisen separately and after that of SMRT, and includes an example of convergent evolution.ConclusionsWe propose that the functions of both SMRT and NCoR have been diversified by alternative splicing during evolution to allow customization for different purposes in different tissues and different species

Employee Satisfaction and Stock Performance

This study aims to explore the previously documented relationship between employee satisfaction and superior stock returns. Previous research suggests that firms with higher employee satisfaction also deliver superior stock returns. Furthermore, previous research has established a logical connection from employee satisfaction to superior stock performance. This study constructed an equally-weighted portfolio of the publicly traded companies on Fortune’s “100 Best Companies to Work For” list. This performance was compared to the performance of the S&P 500 on a total return basis for the calendar years 2015, 2016, 2017, 2018, and 2019. The study also collected fundamental data related to each individual companies’ firm performance and the average firm performance of companies in the S&P 500. The fundamental data collected included return on equity, profit margins, sales growth, and the price to earnings ratio. The results of this study suggest that companies with higher employee satisfaction still deliver higher stock performance and that the anomaly has not been arbitraged away by investors

Review of \u3ci\u3eNative Liberty: Natural Reason and Cultural Survivance\u3c/i\u3e by Gerald Vizenor

Poet, novelist, and critic Gerald Vizenor is arguably the most accomplished and prolific intellectual in the field of Native American studies. His new collection of cultural criticism includes four original essays and nine expanded revisions of uncollected published pieces. Ontic Images, perhaps the finest selection, applies his concept of Native transmotion to representations of Natives in photography. Two perceptive pieces of art criticism discuss the aesthetics and contributions of Anishinaabe artists George Morrison and David Bradley. On the whole, this work serves as a useful introduction to the theory and criticism of this brilliant Anishinaabe (aka Ojibwe, Chippewa) writer